Impossibly airy and flooded with light, this four-bedroom residence, on an enviable corner of a landmarked building, is the essence of unique contemporary style. Ceilings soar to over 10 feet, and every room has a window facing out over the treetops and streets of Tribeca, maximizing the natural glow and creating a coveted sense of volume and brightness. San Francisco–based designer Douglas Durkin-a member of the elite AD 100-guided the home's aesthetics, which are replete with intriguing hues and textures, from blond wood floors and artful mirrors and light fixtures to stunning surfaces of marble and stone.

A key-locked elevator gives way to an alluring entry, a perfect introduction to this spectacular residence. The heart of the home is a tremendously scaled open-plan living room, dining room, and kitchen with multiple seating areas, striking arched windows, sturdy wood and metal columns offering hints of industrial modernism, and abundant lovely light. A sleek, streamlined space for both cooking and dining, the kitchen includes a Calacatta marble–topped island with counter seating, distinctive pendant lighting, and top-caliber stainless-steel appliances, including two Miele dishwashers and a built-in Miele coffee maker. Nearby is a casual dining area with a chic custom banquette set beside a sunny window. At the opposite end of the room, a substantial dining area easily accommodates festive groups for more formal entertaining.

Each of the four bedrooms is serene and gloriously lit. The primary suite includes a spacious, relaxed sitting and media area; two walk-in closets with custom shelving and built-in dressers; and a luxurious bath with heated floors and towel racks, a shower with a pivoting glass door and a rain head, a soaking tub with a backdrop of book-matched Italian Calacatta marble, and a private water closet. Guest bedrooms are accompanied by soigne en suite baths and large, outfitted closets. Walls throughout are ideal for displaying art. Other highlights include a powder room with Duravit fixtures, custom sconces, and flooring, countertops, and a backsplash clad in travertine; a full laundry room; automated solar and blackout shades; recessed lighting throughout with a focus on the proper illumination of art; and built-in speakers.

Originally a bookbindery on a charming cobbled street, the handsome redbrick building at 443 Greenwich was designed by renowned architect Charles C. Haight and built in 1882. With LEED certification in mind, CetraRuddy Architects painstakingly and tastefully restored and transformed the building's interiors to offer an unparalleled combination of generous space and opulent finishes, all in a location affording both convenience-just blocks from the waterfront, the Holland Tunnel, and the Hudson River Greenway-and welcome privacy. The centerpiece of the building an idyllic internal courtyard designed by noted landscape architects HM White, a secret "American woodland" that serves as a stylish reminder of nature's wonders and provides a peaceful escape from the bustle of the city. Residents at 443 Greenwich benefit from a portfolio of amenities, including a 24-hour door attendant; concierge and valet service; a resident manager; a 75-foot indoor lap pool with travertine walls; a playroom; a 5,000-square-foot landscaped roof terrace; a fitness center as well as private fitness studios; locker rooms; a Turkish bath; a climate-controlled wine cellar; additional storage space; and a dramatic subterranean Guastavino-style tiled garage that allows for discreet off-street arrivals and departures.